一、基本信息

董响贵，博士，副教授，硕士生导师。2013年于扬州大学动物科学专业，获学士学位，2019年于中国农业大学动物遗传育种与繁殖专业，获博士学位，2020年-至今，任职于久游手机游戏平台官网动物科技学院。主要致力于家养动物功能基因组学、群体遗传学和进化生物学研究。担任陕西省家兔产业技术体系秘书长，国家特种经济动物科技创新联盟理事，The Innovation Life、《经济动物学报》等期刊青年编委。

通讯地址：陕西省杨凌示范区西农路22号久游手机游戏平台官网动物科技学院

邮编：712100

Email：xgdong@nwafu.edu.cn

二、研究方向

在主要家养动物中，家兔是驯化历史较短的物种之一，在约1400年的驯化过程中形成了丰富的品种资源和表型变异。课题组主要聚焦家兔种质资源，整合多组学测序技术、群体遗传学和比较基因组学等方法，解析家兔由野生祖先到地方品种再到现代培育品种发展过程中重要性状的形成与演化规律，挖掘关键功能基因，揭示重要经济性状（如被毛性状、体重、肉质等）的遗传机制，为家兔分子育种提供理论依据。

课题组另外一个研究方向为林麝基因组学和泌香的分子遗传机制。

三、教学与课程

主讲本科生课程：《经济动物生产学》《动物行为与福利》

参讲研究生课程：《特种动物资源及养殖技术》

参编农业农村部“十四五”规划教材、高等学校“十四五”农林规划新形态教材《特种经济动物生产学》，北京：高等教育出版社，2024.12.

四、科研项目

1.中央高校基本科研业务费，家兔重要性状的适应性进化和系统发育研究，2020-06至2023-05，主持

2.陕西省重点研发计划，基于全基因组关联分析鉴定林麝泌香量的关键基因和分子标记，2022-01至2023-12，主持

3.久游手机游戏平台官网畜牧学一流学科-肉兔新品种培育项目，2022-06至2023-05，主持

4.久游手机游戏平台官网-西藏农牧学院科研联合基金项目，藏鸡产蛋性能遗传特性的解析与利用，2022-05至2024-04，主持

5.校企横向课题，草食动物肠道微生物调控机制研究，2024-01至2027-12，主持

6.国家自然科学基金委员会面上项目，多组学联合解析BRG1对牛肌肉发育相关基因表达的精准调控机制，2025-01至2028-12，参与

7.国家自然科学基金委员会面上项目，ID3介导AMH/Smad信号通路调控鸡卵泡颗粒细胞分化的分子机制，2022-01至2025-12，参与

8.国家自然科学基金委员会面上项目，黑色素细胞影响乌骨鸡产蛋性能的分子机制研究，2019-01至2022-12，参与

五、学术论文

期刊论文

1.Ping X, Chen Y, Wang H, Jin Z, Duan Q, Ren Z, Dong X^*. 2025. Whole-genome sequencing reveals patterns of runs of homozygosity underlying genetic diversity and selection in domestic rabbits. BMC Genomics, 26(1):425

2.Chen Y, Wang H, Ping X, Ahamba Solomon I, Ren Z, Dong X^*. 2025. Two novel SNP variants at ASIP and SNAI2 genes are associated with yellow coat color in rabbits. Animal Genetics 10.1111/age.70006.

3.Wu J, Zhai J, Jia H, Ahamba IS, Dong X^*, Ren Z^*. 2025. Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits. BMC Genomics 26:74.

4.Dong X^#*, Liu Y^#, Chen Y, Ping X, Ren Z, Zhang Y^*. 2024. A chromosome-level genome assembly of Cape hare (Lepus capensis). Scientific Data 11:1081.

5.Song G, Solomon AI, Zhu T, Li Z, Wang S, Song B, Dong X^*, Ren Z^*. 2024. Spatial metabolomics, LC-MS and RNA-Seq reveal the effect of red and white muscle on rabbit meat flavor. Meat Science:109671.

6.Liu C, Hong T, Yu L, Chen Y, Dong X^*, Ren Z^*. 2024. Single-nucleus multiomics unravels the genetic mechanisms underlying musk secretion in Chinese forest musk deer (Moschus berezovskii). International Journal of Biological Macromolecules:135050.

7.Ahamba Solomon I, Mary-Cynthia Ikele C, Kimpe L, Goswami N, Wang H, Li Z, Ren Z, Dong X^*. 2024. Unraveling the genetic and epigenetic landscape governing intramuscular fat deposition in rabbits: Insights and implications. Food Chemistry: Molecular Sciences:100222.

8.Ma H, Zhang H, Deng J, Zhao H, Kong F, Jiang W, Zhang H, Dong X^*, Wang Q^*. 2022. Detection the eDNA of Batrachuperus taibaiensis from the Zhouzhi Heihe River Using a Nested PCR Method and DNA Barcoding. Animals 12.

9.Dong X, Li J, Zhang Y, Han D, Hua G, Wang J, Deng X, Wu C. 2019. Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production. Frontiers in Genetics 10.

10.王慧 赵, 陈苑, 平新新, 王淑辉, 任战军^*, 董响贵^*. 2024. 不同时期伊高乐肉兔与美系獭兔肉质性状的比较与分析. 中国畜牧杂志:1-9

11.Hao R, Ao X, Xu Y, Gao M, Jia C, Dong X, Cirenluobu, Shang P, Ye Y, Wei Z. 2025. Enhancing Oxygen Utilization and Mitigating Oxidative Stress in Tibetan Chickens for Adaptation to High-Altitude Hypoxia. Poultry Science:104893.

12.Gong R, Di X, Ping X, Han H, Song B, Wang S, Dong X, Ren Z. 2025. Exploring the growing phase forest musk deer (Moschus berezovskii) dietary energy requirements based on growth performance and gut microbiota analysis. Microbiology Spectrum 0: e02352-02324.

13.Zhao C, Li Y, Wang H, Solomon AI, Wang S, Dong X, Song B, Ren Z. 2024. Dietary supplementation with compound microecological preparations: effects on the production performance and gut microbiota of lactating female rabbits and their litters. Microbiology Spectrum 0:e00067-00024.

14.Gong R, Chen Y, Li Z, Zhang R, Song B, Wang S, Dong X, Ren Z. 2024. Partially replacing dietary starch with soybean oil improved production performance of weaned Rex rabbits. Journal of Animal Science: skae381.

15.Bo X, Chen J, Mu J, Dong X, Ren Z, Liu J, Wang S. 2023. Quercetin promotes the secretion of musk by regulating the hormone level and microbial structure of forest musk deer. Integrative Zoology.

16.Wang J, Hua G, Chen J, Cui K, Yang Z, Han D, Yang X, Dong X, Ma Y, Cai G, et al. 2023. Epigenetic mechanism of Gtl2-miRNAs causes the primitive sheep characteristics found in purebred Merino sheep. Cell & Bioscience 13:190.

17.Luo G, Mu J, Wang S, Dong X, Ren Z. 2022. Association of blood APMAP content and meat quality trait in Rex rabbits. Anim Biotechnol:1-6.

18.Chen J, Hua G, Han D, Zheng X, Dong X, Wang S, Long J, Zheng Z, Wang A, Wang J, et al. 2021. An EAV-HP insertion in the promoter region of SLCO1B3 has pleiotropic effects on chicken liver metabolism based on the transcriptome and proteome analysis. Scientific Reports 11:7571.

19.Liu C, Wang S, Dong X, Zhao J, Ye X, Gong R, Ren Z. 2021. Exploring the genomic resources and analysing the genetic diversity and population structure of Chinese indigenous rabbit breeds by RAD-seq. BMC Genomics 22:573.

20.Chen J, Dalirsefat SB, Han D, Dong X, Hua G, Zheng X, Xia T, Shao T, Deng X, Wu C. 2020. An EAV-HP insertion in the 5ʹ flanking region of SLCO1B3 is associated with its tissue-expression profile in blue-eggshell Yimeng chickens (Gallus gallus). Poultry Science.

21.Liu S, Jiang S, Dong X, Cui R, Ling Y, Zhao C. 2020. Novel Variants in the HMGA2 Gene Are Associated with Withers Height in Debao Pony. J Equine Vet Sci 88:102948.

22.Darwish HYA, Dalirsefat SB, Dong X, Hua G, Chen J, Zhang Y, Li J, Xu J, Li J, Deng X, et al. 2019. Genome-wide association study and a post replication analysis revealed a promising genomic region and candidate genes for chicken eggshell blueness. PLoS One 14: e0209181.

23.Ma H, Wang S, Zeng G, Guo J, Guo M, Dong X, Hua G, Liu Y, Wang M, Ling Y, et al. 2019. The Origin of a Coastal Indigenous Horse Breed in China Revealed by Genome-Wide SNP Data. Genes 10:241.

24.Zhang Y, Han D, Dong X, Wang J, Chen J, Yao Y, Darwish HYA, Liu W, Deng X. 2019. Genome-wide profiling of RNA editing sites in sheep. Journal of Animal Science and Biotechnology 10:31.

25.Darwish HYA, Zhang Y, Cui K, Yang Z, Han D, Dong X, Mao H, Deng W, Deng X. 2018. Molecular cloning and characterization of the endothelin 3 gene in black bone sheep. Journal of Animal Science and Biotechnology 9:57.

26.Han D, Wang S, Hu Y, Zhang Y, Dong X, Yang Z, Wang J, Li J, Deng X. 2015. Hyperpigmentation Results in Aberrant Immune Development in Silky Fowl (Gallus gallus domesticus Brisson). PLoS One 10: e0125686.

27.Dalirsefat SB, Dong X, Deng X. 2015. Molecular phylogenetic analysis of Chinese indigenous blue-shelled chickens inferred from whole genomic region of the SLCO1B3 gene. Poultry Science.

会议论文

1.Wang H, Ping X, Wang S, Song B, Ren Z, Dong X^*. Identification of Key Genes and lncRNAs Underlying Intramuscular Fat Deposition in Rabbits by RNA Sequencing. 13th World Rabbit Congress (WRC). Tarragona, Spain.2024. (Oral presentation)

2.Dong X, Li J, Deng X, Wu C. Genomic Analyses Reveal Pleiotropic Alleles at EDN3 and BMP7 Affecting Comb Color and Egg Production in Chickens. International Plant & Animal Genome (PAG) XXVII. 2019. San Diego, CA. (Poster presentation)

3.刘晨苗，任战军，董响贵^*.利用单细胞多组学技术解析林麝麝香腺发育及麝香分泌调控机制. 第九届中国林业学术大会.杨凌.2024.(受邀报告)

4.董响贵，李俊英，邓学梅，吴常信.全基因组关联分析揭示东乡绿壳蛋鸡产蛋量的变异位点. 第二十次全国动物遗传育种学术讨论会.广州.2019. (优秀论文奖)

5.董响贵，李俊英，张媛媛，邓学梅，吴常信. 选择性清除分析揭示鸡冠色和产蛋量的潜在关系. 第十九次全国动物遗传育种学术讨论会.南京.2017. (报告)

6.董响贵，李俊英，张媛媛，邓学梅，吴常信. 绿壳蛋鸡冠色的全基因组关联分析. 第十八次全国动物遗传育种学术讨论会.南昌.2015. (报告)